SYNTHESIS OF E-CHALCONE DERIVATIVES BEARING DIFFERENT SUBSTITUENT GROUPS AND EVALUATION OF SUBSTITUENT EFFECTS ON THEIR SPECTROSCOPIC PROPERTIES

http://doi.org/10.71284/jasem202611

Abstract

Chalcones are simple yet significant structures containing various examples of enolate chemistry. Nowadays, these compounds can be synthesized in various ways, such as through methods like Claisen-Schmidt condensation. This method is commonly used due to its ease of application, high efficiency, and method diversity in synthesis. Due to their unsaturated structures, Chalcone derivatives can be used in different addition reactions. Also, they can be modified with various functional groups to achieve desired properties using simple starting reactants. These advantages make chalcone derivatives suitable for a wide range of applications. In addition to sensor applications, chemical probes, and fluorescence dyes, chalcone derivatives attract considerable attention in medical applications because of their diverse pharmacological activities such as anticancer, anti-HIV, and antibacterial activities.

In this study, various chalcone derivatives bearing suitable functional groups were synthesized, and their structures were characterized while their optical properties were systematically investigated. The structural analyses performed following the syntheses not only confirmed the structures of the synthesized compounds but also examined and substantiated the effects of the functional groups present on the corresponding molecular scaffold in terms of NMR and optical properties.