DETERMINATION OF COPEPTIN AND OXIDATIVE STRESS MARKERS IN HEART FAILURE PATIENTS

Abstract

This study aimed to determine the increase in copeptin levels in patients with heart failure and to compare them with those in a control group. Additionally, liver enzyme levels, renal function markers, and antioxidant levels were compared with those in a control group. Finally, the relationship between copeptin and all biochemical variables studied was analyzed. Copeptin and troponin variables were measured using an ELISA device, while liver enzymes and renal variables (AST, ALT, Urea, and Creatinine) were assessed using an Otto device. Antioxidants were measured colorimetrically using a spectrophotometer. The study included 100 participants, divided into two groups: a healthy group (n = 50) and a heart failure patient group (n = 50). Copeptin and troponin values ​​were found to be higher in patients with heart failure compared to the control group. Additionally, there were significant increases in renal markers and liver enzymes in the patient group compared to the control group. In patients with heart failure, levels of GSH, GPx, and SOD decreased compared to the control group, while MDA levels increased. Copeptin levels were significantly higher in heart failure patients than in the control group, making it a potential indicator of heart-related problems.